Ahmed J. Qasim
Supervisor Name :Dr. Ahmed W.Naser
Different new heterocyclic compounds derived from Flurbiprofenhydrazide  as starting material were synthesized. The Schiffbases [3a-d] were obtained by condensation of  with some aldehyde such as 2,4-Dimethoxybenzaldehyde, 4-(N,N-Dimethylamino) benzaldehyde, 3- Hydroxybenzaldehyde and 2-Hydroxybenzaldehyde. The cyclization of [3ad] with phenylisocyanate gave the corresponding Aza-β-Lactm compounds [8a-d]. The reaction of  with some acidanhydride such as Maleic anhydride, Succinic anhydride and Phthalic anhydride gave corresponding ciclicimide derivatives [4a-c]. Oxazpine derivatives [5a-d], [6a-d] and [7ad] were prepared by cycloaddition of Schiff-bases [3a-d] with some acidanhydride such as Maleic anhydride, Succinic anhydride and Phthalic anhydride. FT-IR, 1H-NMR and 13C-NMR were used to characterize the target compounds.